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Spravato (Esketamine) Treatment for Depression

Vanguard Neuro Psychiatry offers SPRAVATO® (esketamine) nasal spray, the first and only monotherapy for adults with treatment-resistant depression.

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SPRAVATO® (esketamine) nasal spray
Spravato Device

What is SPRAVATO®?

SPRAVATO® is an FDA-approved esketamine nasal spray used to treat adults with treatment-resistant depression (TRD) and depressive symptoms in those with major depressive disorder (MDD) who have suicidal thoughts or actions.

Approved in 2019, it is taken with or without an oral antidepressant for TRD and alongside an oral antidepressant for MDD with suicidal thoughts or actions.

View Indications & Safety Info

How to get started

1. NO-COST CONSULTATION

Learn about SPRAVATO® nasal spray

You will first talk with one of our intake specialists, who will collect some basic information and arrange a meeting with one of our Consult Coordinators. The Consult Coordinator can meet with you in person, over video conference, or on the phone and will review your history and explain aspects of esketamine nasal spray treatment.

We focus on insurance so you don't have to

Your Care Team will also explain treatment payment options and review standard insurance plan criteria with you. We will coordinate with your health insurance provider to determine benefits.

Is SPRAVATO® covered by insurance?

Yes! Many major insurance companies cover SPRAVATO® if you haven't found adequate relief after trying just TWO oral antidepressants.

A benefit of having treatment at a Vanguard center is that our Care Team does all the work for you regarding insurance. We assist all patients with the coverage and reimbursement process.

Learn More About Coverage Schedule a No-Cost Consultation
Should I receive IV Ketamine or SPRAVATO® (Nasal Esketamine)?
IV ketamine
  • Is not FDA-approved for the treatment of depression
  • Is not covered by many insurance companies
  • Is not offered at Vanguard
SPRAVATO® (esketamine) nasal spray
  • Is FDA-approved for the treatment of depression
  • Is covered by many insurance companies
  • Is offered at Vanguard
2. PRE-ASSESSMENT

Find out if SPRAVATO® nasal spray is right for you

Next, you will meet with a Vanguard affiliated provider for an evaluation, which includes questions about your history and symptoms.

If the Vanguard provider has determined that you are a candidate for esketamine nasal spray and you are ready to move forward, they will create your individualized treatment plan.

You're ready to start
feeling better!

At most Vanguard centers, we try to book your SPRAVATO® treatments to accommodate your schedule, whether morning or afternoon appointments work best for you.

After you arrive at the center, you will be placed in a reclining chair where you can sit back and relax. You will be handed a nasal spray device to self-administer. Your care team will supervise you for at least two hours. Afterward, you will need someone to drive you home from treatment. By the next morning, most people are ready to resume their day with no restrictions.

Typical SPRAVATO® Treatment Session
  • 1
    Arrive in the center and relax in a chair
  • 2
    The spray is handed to you and you self-administer it
  • 3
    Relax while our Care Team supervises
  • 4
    Have someone drive you home
Medical Icon

Your safety and comfort are
our top priorities

During SPRAVATO® treatment, you may feel dizzy or euphoric. Our Care Team will be there to assist you throughout your treatment. Your blood pressure will be checked upon arrival, 40 minutes in, and before you leave.

After your two-hour treatment, you may be groggy and woozy. You will need to avoid hazardous activity for the remainder of the day, including operating a motor vehicle, so you will need someone to drive you home from treatment.

Learn More about SPRAVATO®

SPRAVATO® Treatment Phases

Treatment plans may vary depending on clinical conditions.

Induction
Phase 1 Calendar Phase 1
Week 1-4

2 treatments each week

Maintenance
Phase 2 Calendar Phase 2
Week 5-8

1 treatment each week

Maintenance
Phase 3 Calendar Phase 3
Week 9+

1 treatment every 1-2 weeks

SPRAVATO® FAQs

SPRAVATO® is the brand name for esketamine, which is a derivative of ketamine. While ketamine is delivered via IV and used off-label for depression, SPRAVATO® is an FDA-approved nasal spray specifically formulated for treatment-resistant depression.

It is for adults with treatment-resistant depression (TRD) who have tried at least two different oral antidepressants without sufficient relief, or adults with major depressive disorder accompanied by suicidal thoughts.

The initial course is typically 4 weeks (twice a week), followed by a maintenance phase where treatments are gradually reduced to once a week, and eventually once every 1-2 weeks based on your specific clinical needs.

Dosage starts at 56 mg or 84 mg depending on the individual and physician recommendation, administered under strict supervision.

Yes, SPRAVATO® is actually designed to be taken in conjunction with a daily oral antidepressant.

No. SPRAVATO® is administered in our comfortable, certified Vanguard outpatient clinics under the supervision of our Care Team.

You should not take it if you have a history of aneurysms or arteriovenous malformations, or a history of bleeding in the brain.

Yes! Most major commercial insurance plans, as well as Medicare, cover SPRAVATO® for patients who meet the medical criteria (usually having tried two prior antidepressants without success).

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Click here for Indications and Important Safety Information